Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: poorly documented methods, no single values given

Data source

Reference
Reference Type:
publication
Title:
Range-finding Toxicity data: List VII
Author:
Henry F. Smyth Jr. Ph.D. , Charles P. Carpenter Ph.D. , Carrol S. Weil , Urbano C. Pozzani , Jean A. Striegel & Judith S. Nycum
Year:
1969
Bibliographic source:
American Industrial Hygiene Association Journal, 30:5, 470-476

Materials and methods

Principles of method if other than guideline:
Concentrated vapor inhalation consists of subjecting groups of six male or female albino rats to a flowing stream of vapor-ladened air. The vapor-air mixture is generated by passing 2.5 liters/minute of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch inapproximately 50 ml of the test chemical contained in a gas-washing bottle.
GLP compliance:
no
Test type:
other: Estimation of exposure time where no mortality occurs in vapour-containing air flow.
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: concentrated vapour

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
clean air
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
No. of animals per sex per dose:
6 (total) male or female
Control animals:
no
Details on study design:
Inhalations are continued for time periods in a logarithmic series with a ratio of two extending from one-fourth to eight hours, until the inhalation
period killing about half the number of rats within 14 days is defined.
Statistics:
not given

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: see remarks
Effect level:
other: no mortality
Based on:
other: concentrated vapour
Exp. duration:
8 h
Remarks on result:
other: only the exposure time in the prepared air/concentrated vapor atmosphere with no mortality is given.
Mortality:
no mortality
Clinical signs:
not examined
Body weight:
not examined
Gross pathology:
not examined

Applicant's summary and conclusion

Executive summary:

Inhalative exposure to a concentrated vapour atmosphere was tolerated by 6 male Wistar rats for 4 hours without mortality