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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: poorly documented methods, no single values given

Data source

Reference
Reference Type:
publication
Title:
Range-finding Toxicity data: List VII
Author:
Henry F. Smyth Jr. Ph.D. , Charles P. Carpenter Ph.D. , Carrol S. Weil , Urbano C. Pozzani , Jean A. Striegel & Judith S. Nycum
Year:
1969
Bibliographic source:
American Industrial Hygiene Association Journal, 30:5, 470-476

Materials and methods

Principles of method if other than guideline:
Concentrated vapor inhalation consists of subjecting groups of six male or female albino rats to a flowing stream of vapor-ladened air. The vapor-air mixture is generated by passing 2.5 liters/minute of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch inapproximately 50 ml of the test chemical contained in a gas-washing bottle.
GLP compliance:
no
Test type:
other: Estimation of exposure time where no mortality occurs in vapour-containing air flow.
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl phosphonate
EC Number:
212-091-6
EC Name:
Diethyl phosphonate
Cas Number:
762-04-9
Molecular formula:
C4H11O3P
IUPAC Name:
diethyl phosphonate
Test material form:
other: concentrated vapour

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
clean air
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
No. of animals per sex per dose:
6 (total) male or female
Control animals:
no
Details on study design:
Inhalations are continued for time periods in a logarithmic series with a ratio of two extending from one-fourth to eight hours, until the inhalation
period killing about half the number of rats within 14 days is defined.
Statistics:
not given

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: see remarks
Effect level:
other: no mortality
Based on:
other: concentrated vapour
Exp. duration:
8 h
Remarks on result:
other: only the exposure time in the prepared air/concentrated vapor atmosphere with no mortality is given.
Mortality:
no mortality
Clinical signs:
other: not examined
Body weight:
not examined
Gross pathology:
not examined

Applicant's summary and conclusion

Executive summary:

Inhalative exposure to a concentrated vapour atmosphere was tolerated by 6 male Wistar rats for 4 hours without mortality