Barbituric acid

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Report date:

2012

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)

GLP compliance:

yes (incl. QA statement)

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

azobarbituric acid

IUPAC Name:

azobarbituric acid

Constituent 2

Reference substance name:

2,4,6(1H,3H,5H)-Pyrimidintrion, 5,5'-(1,2-diazendiyl)bis-

IUPAC Name:

2,4,6(1H,3H,5H)-Pyrimidintrion, 5,5'-(1,2-diazendiyl)bis-

Constituent 3

Reference substance name:

25157-64-6

EC Number:

607-578-9

Cas Number:

25157-64-6

IUPAC Name:

25157-64-6

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

Red powder

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

arachis oil

Doses:

300 mg/kg bw
2000 mg/kg bw

No. of animals per sex per dose:

1 animal for dose 300 mg/kg bw
5 animals for 2000 mg/kg bw

Control animals:

no

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

for both doses:
no mortality

Clinical signs:

for both doses:
No signs of systemic toxicity were noted during the observation period.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The acute oral median lethal dose (LD50) of the test item in the female Wistar strain rat was estimated to be greater than 2000 mg/kg bodyweight.