Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Tissue response to a single intraperitoneal injection of various substances in rats.
Author:
SETHI, S., HILSCHER, W., & FLASBECK, R.
Year:
1973
Bibliographic source:
Zbl. Bakt. Hyg. I. Abt. Orig. B., 157: 131-144.
Reference Type:
publication
Title:
High concentration of injected titanium dioxide in abdominal lymph nodes.
Author:
HUGGINS, C.B. & FROEHLICH, J.P.
Year:
1966
Bibliographic source:
J. exp. Med., 124: 1099-1106
Reference Type:
publication
Title:
Acute oral and parenteral toxicity of four titanate compounds in the rat
Author:
BROWN, J.R., MASTROMATTEO, E.
Year:
1962
Bibliographic source:
Ind. Med. Surg., 31: 302-304
Reference Type:
publication
Title:
Effect of BCG on lymphatic lung clearance of dust with different fibrogenicity. An experimental study on rats.
Author:
GOTHE, C.-J., SWENSSON, U.
Year:
1970
Bibliographic source:
Arch. environ. Health, 20: 579-585
Reference Type:
publication
Title:
Papain-induced emphysema and the elimination of TiO2 particulates from the lungs.
Author:
FERIN, J.
Year:
1971
Bibliographic source:
Am. Ind. Hyg. Assoc. J., 32: 157-162
Reference Type:
publication
Title:
Emphysema in rats and clearance of dust particles.
Author:
FERIN, J.
Year:
1971
Bibliographic source:
Inhaled particles and vapours. III. 3rd ed., United Kingdom, Unwin Brothers Ltd. pp. 283-292.
Reference Type:
publication
Title:
Observations concerning alveolar dust clearance.
Author:
FERIN, J.
Year:
1972
Bibliographic source:
Ann. N.Y. Acad. Sci., 200: 66-72
Reference Type:
publication
Title:
The effects of SO2 on lung clearance of TiO2 particles in rats
Author:
FERIN, J. & LEACH, L.J.
Year:
1973
Bibliographic source:
Am. Ind. Hyg. Assoc. J., 34: 260-263

Materials and methods

Results and discussion

Applicant's summary and conclusion