Registration Dossier

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report Date:
1982

Materials and methods

Test type:
acute toxic class method
Limit test:
no

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals and environmental conditions:
Test animals:
Wistar rats, females, ca. 14 weeks old. Average weight at the beginning of the test: 161 g.
Tested in groups of 5 animals. Conditions: 22 +/- 1.5°C; 12h light/dark cycle; humidity 60 +/- 5%
Source: Winkelmann, Borchen

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
polyethylene glycol
Details on oral exposure:
The test substance was composited with Lutrol (polyethylene glycol) and administered by gavage.
The mixture was given once.
Doses:
100, 500, 800, 900, 1000, 1500 mg/kg bw
No. of animals per sex per dose:
10

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
786 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Conclusions:
The LD50 value for acute oral toxicity is 786 mg/kg bw in female Wistar rats.