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EC number: 444-960-2 | CAS number: 39148-16-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 Jul - 09 Sep 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Version / remarks:
- 2012
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control and 10 mg/L
- Sampling method: 5 mL water samples were taken from all test solutions at the beginning (0 d), immediately prior to the first renewal of the test solution (3 d) and weekly thereafter (9, 21 d). - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: A stock solution was prepared with a concentration of 1000 mg/L by dissolving 0.1025 g test substance in 100 mL deionized water (the concentration was adjusted by the purity of 97.6%). Test solution was prepared by dilution of the stock solution with Elendt M7 medium. For the limit concentration of 10 mg/L 0.5 mL of the stock solution was diluted to a total volume of 50 mL with M7 medium.
- Controls: M7 medium was used as negative control - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Age at study initiation (mean and range, SD): < 24 h
- Source: all organisms originated from cultures established from the same healthy stock of daphnia
- Feeding during test : yes
- Food type: concentrated solutions of Chlorella vulgaris
- Amount: 0.1 - 0.2 mg/C/Daphnia per day
- Frequency: once per day
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 21 d
- Hardness:
- 221 - 232 mg CaCO3/L
- Test temperature:
- 20 - 21 °C
- pH:
- 7.4 - 7.8
- Dissolved oxygen:
- 90 - 101% of the air saturation value
- Nominal and measured concentrations:
- - Nominal concentrations: control, 10 mg/L
- Measured concentrations control: see results - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beaker
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: 50 mL
- Aeration: none
- Renewal rate of test solution (frequency/flow rate): test solutions were renewed every 72 hours
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
- Biomass loading rate: 50 mL of test solution/daphnid
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Elendt M7 medium was used as dilution medium
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light, 8 hours darkness
- Light intensity: 1000 - 1500 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : number of living offspring was counted for each vessel daily. Offspring produced was removed and counted daily from the appearance of the first brood to prevent them consuming food intended for adults. Test concentrations were analysed at the beginning (0 d), immediately prior to the first renewal of the test solution (3 d) and weekly thereafter (9, 21 d). Determination of test substance concentrations prior to renewal was performed on one seperate vessel at each test concentration. Oxygen concentration, pH, hardness, and temperature were measured once a week in the control and test concentrations. Observations were made on time to production of first brood and number of broods per surviving parental daphnia.
TEST CONCENTRATIONS
- Range finding study: yes
- Test concentrations: control, 1.0, and 10 mg/L
- Results used to determine the conditions for the definitive study: no dead daphnia at any tested concentration - Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: and adult survival
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: and adult survival
- Reported statistics and error estimates:
- For the estimation of the lowest observed effect concentration (LOEC), and the no observed effect concentration (NOEC), for the effects of the target substance on growth rate, the mean growth rate for each concentration were compared with the control mean using a multiple comparison method of independent samples t-test.
- Validity criteria fulfilled:
- yes
- Remarks:
- see Table 4 in 'any other information on results incl. tables'
Reference
Table 1. Measured concentrations of Fosetyl-Na in test medium
Nominal concentration (mg/L) |
Analyzed concentration (mg/L) |
Mean analyzed concentration (mg/L) |
|||||
|
Day 0 |
Day 3 |
Day 9 |
Day 21 |
|
||
|
fresh |
aged |
fresh |
aged |
fresh |
aged |
|
Control |
< LOD |
< LOD |
< LOD |
< LOD |
< LOD |
< LOD |
- |
10.0 |
9.29 |
9.17 |
9.14 |
9.01 |
9.27 |
9.25 |
9.19 |
Table 2. Summary of offspring data in a 21 day reproduction test with daphnia magna
Replicate |
Offspring number |
Number of dead adults |
||
Control |
10.0 mg/L |
Control |
10.0 mg/L |
|
1 |
61 |
58 |
0 |
0 |
2 |
74 |
64 |
0 |
0 |
3 |
62 |
58 |
0 |
0 |
4 |
64 |
65 |
0 |
0 |
5 |
59 |
55 |
0 |
0 |
6 |
63 |
62 |
0 |
0 |
7 |
61 |
60 |
0 |
0 |
8 |
64 |
68 |
0 |
0 |
9 |
63 |
41 |
0 |
0 |
10 |
61 |
68 |
0 |
0 |
Table 3. Summary of fecundity
Nominal concentration in mg/L |
Initial number of adults |
21 d |
|
Mean Fecundity (No. live offspring per adult) |
Inhibition rate (%) |
||
|
|
|
|
Control |
10 |
63 |
- |
10.0 |
10 |
60 |
5.59 |
Table 4. Validity criteria OECD 211
Criterion from the guideline |
Outcome |
Validity criterion fulfilled |
The mortality of parent animals in the control should not exceed 20% at the end of the test. |
Mortality was 0% |
Yes |
The mean number of living offspring produced per parent animal in the control surviving at the end of the test should be ≥ 60. |
61 - 74 animals |
Yes |
Description of key information
NOEC (21 d, immobilisation and reproduction) ≥ 10 mg/L (nominal) for Daphnia magna (OECD 211)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- >= 10 mg/L
Additional information
A GLP study on the long-term toxicity to aquatic invertebrates is available for Fosetyl-sodium. The study was conducted according to OECD guideline 211 on the chronic toxicity of Fosetyl-Sodium to Daphnia magna was under semi-static conditions. Daphnia were exposed to the nominal limit concentration of 10 mg/L and an untreated control at 20 - 21 °C for 21 days. The test item was dissolved in test water. No additional solvent was used. The test water was not aerated during the time of testing.
Analysis of 5 mL water samples taken from all test solutions at the beginning (0 d), immediately prior to the first renewal of the test solution (3 d) and weekly thereafter (9, 21 d) showed that the measured concentrations were within +/- 20% of nominal concentrations. Therefore, the results were based on nominal concentrations. No mortality or abnormal behaviour was observed in any treatment at the end of the study and the mean living offspring number per adult daphnid was 63 for the control and 60 in the limit concentration (10 mg/L). Thus, the study is valid according to OECD guideline 211 and the 21-day NOEC for reproduction and survival in Daphina magna is ≥ 10 mg/L (nominal).
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