Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 951-619-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-11-19 til 2019-02-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Principles of method if other than guideline:
- NA
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, adapted
- Details on inoculum:
- Sludge collection: a fresh sample of activated sludge was collected on Dec 27, 2018 from the aeration tank ofthe Long Hua Wastewater Treatment Plant in Shanghai
which treats predominantly domestic sewage. The activated sludge was kept by aeration until used (non-aeration during transport from the wastewater treatment plant
to the laboratory was kept to a minimum). Sludge treatment: When back to the laboratory, the sludge was washed with mineral medium.
After centrifugation, the supernatant was decanted. This procedure was repeated three times (4000rpm, 4°C, centrifuge 20 minutes). Then, 0.401g of the concentrated sludge was weighed, dried at 105°C for 1 h and then measured by moisture meter for 1 h to determine the dry weight. The dry weight of concentrated sludge was 9.73%.
Sludge suspension: According to the dry weight, 30.8 g of concentrated sludge was calculated and suspended in 1 L mineral medium to yeild a concentration of 3g suspended solids/L. The final concentration of the activated sludge in the test medium was 30 mg/L. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 17.4 mg/L
- Based on:
- test mat.
- Remarks:
- final concentration was clearly above water solubility
- Parameter followed for biodegradation estimation:
- O2 consumption
- Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (O2 consumption)
- Value:
- 3
- Sampling time:
- 28 d
- Details on results:
- Under the test conditions no biodegradation of test item could be observed.
The percentage degradation did not exceed 60 % within the 10-day window and after 28 days of incubation.
The test item is considered not readily biodegradable.
The reference Item sodium sodium benzoate was sufficiently degraded to 89 % and 97 % after 14 and 28 days, respectively. The percentage degradation (> 60 % after 14 days) of the reference item confirms the suitability of the used activated sludge inoculum.
The toxicity control showed a degradation of the reference compound in presence of the test material of 69% and 78% after 14 and 28 days, respectively. The test material was thus not toxic to the bacteria. - Results with reference substance:
- The reference Item sodium sodium benzoate was sufficiently degraded to 89 % and 97 % after 14 and 28 days, respectively. The percentage degradation of the reference item confirms the suitability of the used activated sludge inoculum.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Under the test conditions no biodegradation of test item could be observed. The percentage degradation did not exceed 60 % within the 10-day window and after 28 days of incubation. The test item is considered not readily biodegradable.
- Executive summary:
In this OECD 301F Assay the results show no biodegradation of test item.
The percentage degradation did not exceed 60 % within the 10-day window and after 28 days of incubation.
The test item is considered not readily biodegradable.
The reference Item sodium sodium benzoate was sufficiently degraded to 89 % and 97 % after 14 and 28 days, respectively. The percentage degradation of the reference item confirms the suitability of the used activated sludge inoculum.
The toxicity control showed 69 and 78 % degradation after 14 and 28 days respectively. According to the test guidelines the test item can thus be assumed to be not inhibitory on the activated sludge micro organisms because degradation was > 25% within 14 days.
Reference
Description of key information
OECD 301F: not readily biodegradable
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.