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Diss Factsheets
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EC number: 424-650-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.5 (Degradation: Biochemical Oxygen Demand)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.6 (Degradation: Chemical Oxygen Demand)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Duration of test (contact time):
- >= 28 d
- Initial conc.:
- >= 0.99
- Initial conc.:
- >= 1.98
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Test substance was added on a filter to the stoppered test bottles which were then filled with the natural seawater medium. Concurrent controls were also established. The oxygen concentration was measured using an oxygen electrode after 5, 20 and 28 days. Temperature, pH was also recorded.
- Reference substance:
- other: ethanol
- Test performance:
- The mean maximum biochemical oxygen demand of 0.12 mg O2/mg was reached after 20 days.
- Remarks on result:
- other: see BOD5 results below
- Parameter:
- BOD5
- Value:
- 0.07 mg O2/g test mat.
- Remarks on result:
- other: test conc. 1.98 mg/l
- Parameter:
- COD
- Value:
- 3 other: %
- Remarks on result:
- other: test conc. 1.98 mg/L
- Parameter:
- BOD5
- Value:
- 0.11 mg O2/g test mat.
- Remarks on result:
- other: test conc. 0.99 mg/L
- Parameter:
- COD
- Value:
- 4
- Remarks on result:
- other: test conc. 0.99 mg/L
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The degradation of Donor C20 appeared to be low, being <= 5% based on it's COD or ThOD value. Donor C20 is considered to not be biodegradable in this test.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Qualifier:
- according to guideline
- Guideline:
- other: GB/T 21831-2008: Chemicals-Ready Biodegradability Closed Bottle Test
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Shanghai Longhua Sewage Plant
- Preparation of inoculum for exposure: Aeration of the secrdary effluent for 7 days at the test temperature of 20 +/- 1C
- Concentration of sludge: 1.4 x 105 orgs/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 4 mg/L
- Based on:
- ThOD
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral Medium,
a) KH2PO4 8.50g; K2HPO4 21.75g; NaHPO4-2H2O 334g; NH4Cl 0.5g. Dissolved in water and make up to 1 litre, pH 7.4
b) CaCl2 27.50g. Dissolved and make up to 1 litre
c) MgSO4.7H2O 22.50g. Dissolved and make up to 1 litre
d) FeCl.6H20 0.25. Dissolved and make up to 1 litre
1 mL of of solutions a), b), c) and d) with 800 ML and then make up to 1 litre
- Test temperature: 20C +/- 1C
- Aeration of dilution water: No
TEST SYSTEM
- Number of culture flasks/concentration: 2
- Measuring equipment: DIssoved oxygen meter (Model YSI-58)
- Test performed in closed vessels due to significant volatility of test substance: Yes
- Test performed in open system: No
SAMPLING
- Sampling frequency: 1d, 4d, 7d, 14d, 18d, 21d, 24d, 28d
- Sterility check if applicable: No
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Toxicity control: yes
STATISTICAL METHODS:
Not applicable - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2.9
- Sampling time:
- 28 d
- Remarks on result:
- other: mean of replicates (duplicates)
- Details on results:
- The validity criteria of the test was met:
Blank control: O2 consumption was 0.8 mg/ DO/l (did not exceed 1.5 mg DO/l after 28 days)
Reference substance: Degradation >60% after 14 days
Toxicity control: O2 consumption of the toxicity contro after 14 days was 3.5 mg/L (greater than reference group 3.4 mg/L
Residual O2 concentration : did not fall below 0.5 mg/l throughout the test
Replicates: Difference was less than 20%
No inhibition observed in the toxicity control - Results with reference substance:
- See table below
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test substance was not ready biodegradable in this test.
Referenceopen allclose all
% Degradation results
Test substance | Reference substance | ||||
1d | Replicates | 0.7 | 0.4 | - | - |
1d | Average | 0.5 | - | ||
4d | Replicates | 1.6 | 1.3 | - | - |
4d | Average | 1.4 | - | ||
7d | Replicates | 2.0 | 1.8 | 80.8 | 80.5 |
7d | Average | 1.9 | 80.7 | ||
11d | Replicates | 2.1 | 2.0 | - | - |
11d | Average | 2.1 | - | ||
14d | Replicates | 2.6 | 2.3 | 87.1 | 86.8 |
14d | Average | 2.5 | 87.0 | ||
18d | Replicates | 2.8 | 2.7 | - | - |
18d | Average | 2.7 | - | ||
21d | Replicates | 3.1 | 2.4 | 88.8 | 88.2 |
21d | Average | 2.8 | 88.5 | ||
24d | Replicates | 3.2 | 2.5 | - | - |
24d | Average | 2.9 | - | ||
28d | Replicates | 3.0 | 2.7 | 88.9 | 89.5 |
28d | Average | 2.9 | 89.2 |
Description of key information
Two reliable studies were available to determine biodegradability of the substance. Using different guideline methods, the results indicate that the substance is not biodegradable with <5% biodegradation seen at the end of the test within each study.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.