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EC number: 686-816-3 | CAS number: 151840-68-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- 1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The source compound [Bis(1,3-dimethylcyclopentadienyl)zirconium dichloride] (CAS No. 119445-92-0) is structurally identical to the target compound [Bis(1-butyl-3-methylcyclopentadienyl)zirconium dichloride] (CAS No. 151840-68-5), with the exception of the presence of a butyl, rather than a methyl group, on the C1 position of both cyclopentadiene rings. Both substances share the same organozirconium structure, comprising of a zirconium central atom, with two cyclopentadienyl rings and two chlorine ligands. Although metabolic data is not available for both substances, they are expected to decompose to identical breakdown products.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Bis(1-butyl-3-methyl cyclopentadienyl)Zirconium dichloride
- EC Number:
- 686-816-3
- Cas Number:
- 151840-68-5
- Molecular formula:
- C20 H30 CL2 Zr1
- IUPAC Name:
- Bis(1-butyl-3-methyl cyclopentadienyl)Zirconium dichloride
- Test material form:
- solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- Not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- A single administration of the substance was administered into the conjuctival sac of the left eye. Both eyes were rinsed with water 24 hours after the test substance application.
- Observation period (in vivo):
- 1 hour, 24 hours and 144 hours after instillation. Examination 168 hours after instillation was impossible because of severe inflammation of the eye.
- Number of animals or in vitro replicates:
- Three (3) rabbits.
- Details on study design:
- Not specified.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: all three rabbits
- Time point:
- other: 1 hour
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: all three rabbits
- Time point:
- 24 h
- Score:
- >= 1 - <= 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal: all three rabbits
- Time point:
- other: 1 hour
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal: all three rabbits
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal: all three rabbits
- Time point:
- other: between 1 hour and 168 hours after instillation
- Score:
- >= 3 - <= 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Corneal opacity (grade 1) occurred in all three rabbits 1 h after instillation, in grades 1-4 in all three rabbits between 24 h and 144 h after instillation. Because of severe inflammation an evaluation was impossible at the examination 168 h after instillation. The whole cornea was affected at each time-point of examination. From 24 h after dosing onwards the iris of all 3 rabbits did not show any reaction to light, this alteration had not disappeared at study termination. Conjunctival redness (grade 1) occurred 1 h after instillation in all three rabbits, redness increased up to grade 2 between 24 h and 158 h after instillation. Conjunctival chemosis (grades 3-4) was observed between 1 h and 168 h after the instillation in all 3 rabbits. All 3 animals showed conjunctival secretion (grades 1-3) between 1 h and 168 h after the instillation. Secretion was hemorrhagic and purulent after 24 h in all rabbits. The fluorescein test confirm cd corneal changes in form of ulceration and/or necrosis.
Examination after 168 h revealed a very poor general condition of the rabbits as a consequence of the afore-described local changes. Therefore the 3 animals had to be sacrificed at this time-point. - Other effects:
- Bodyweight gain and food consumption were within the normal range. The right eye remained untreated and showed no pathological changes.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Based on the results of this study, Bis (1, 3-dimethylcyclopentadienyl) zirconium dichloride is considered to be severely irritating to the eye.
- Executive summary:
In the present examination, the effect of Bis (1, 3-dimethylcyclopentadienyl) zirconium dichloride on the rabbit eye was tested after a single administration into the conjunctival sac. Under the present test conditions, 0.1 g Bis (1, 3-dimethylcyclopentadienyl) zirconium dichloride/eye showed severe adverse effects (both eyes were rinsed with water 24 h after the test substance application). Although the data was not available on an individual animal basis, these data would not have affected the overall severity of the conclusion. Based on the results of this study Bis (1, 3-dimethylcyclopentadienyl) zirconium dichloride is considered to be severely irritating to the eye.
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