Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
NTP reference value

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1990
Report Date:
1990

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Version / remarks:
no guideline specified, but result considered by NTP as reliable
Deviations:
not specified
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
male
Dose descriptor:
LC50
Remarks:
rats
Effect level:
ca. 88 480 other: mg.min/m3
Based on:
test mat.
Key result
Sex:
male
Dose descriptor:
LC50
Remarks:
mouse
Effect level:
ca. 50 010 other: mg.min/m3
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In rats, NTP (1990) reported LC50 by inhalation in male rats of 88 480 mg x min/m3 and in male mice of 50 010 mg x min/m3