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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1989
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Well documented literature data compilation

Data source

Reference
Reference Type:
publication
Title:
Fluorene derivatives as radioprotectant drugs
Author:
G. G. Vatulina
Year:
1989
Bibliographic source:
Pharmaceutical Chemistry Journal, 1989 23(4):325-329, DOI: 10.1007/BF00758424

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
i.p. administration of a solution to mice
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Fluoren-9-one
EC Number:
207-630-7
EC Name:
Fluoren-9-one
Cas Number:
486-25-9
Molecular formula:
C13H8O
IUPAC Name:
9H-fluoren-9-one

Test animals

Species:
mouse
Strain:
C57BL
Sex:
male/female
Details on test animals or test system and environmental conditions:
Age: 3-3.5 month
Weigth: 18-20 g

Administration / exposure

Route of administration:
other: IP
Vehicle:
other: Tween-Water=1:9
Doses:
2000 mg/kg bw
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: intra peritoneally administration

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute toxicity after single ip administration to mice exceeds 2000 mg/kg bw.