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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
not specified
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
The effects of administration of sodium iodate to man and animals
Author:
Murray MM
Year:
1953
Bibliographic source:
World Hlth Org. (9) 211-216

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Acute toxicity tests were made on mice by Dr. W. L. M. Perry at the National Institute for Medical Research, London. This publication reports on the results from these tests.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: mortality (mice)
Effect level:
250 mg/kg bw
Based on:
not specified
Remarks on result:
other: 0/10 mice died at this dose level
Sex:
not specified
Dose descriptor:
other: mortality (mice)
Effect level:
750 mg/kg bw
Based on:
not specified
Remarks on result:
other: 7/10 mice died at this dose level
Sex:
not specified
Dose descriptor:
other: mortality (mice)
Effect level:
2 500 mg/kg bw
Based on:
not specified
Remarks on result:
other: 10/10 mice died at this dose level
Mortality:
None of the animals dosed at 250 mg/kg bw died. At the dose level of 750 mg/kg bw 7 of the 10 animals died within 3 weeks. At 2500 mg/kg bw all of the animals died within 12 hours.

Applicant's summary and conclusion

Conclusions:
Following single oral administration of the test material to groups of 10 mice at dose levels of 250, 750 and 2500 mg/kg bw produced 0, 7 and 10 deaths, respectively.
Executive summary:

The test material was dosed to groups of 10 mice at dose levels of 250, 750 and 2500 mg/kg bw.

No symptoms were reported in the group dosed at 250 mg/kg bw. At the dose level of 750 mg/kg bw 7 of the 10 animals died within 3 weeks. At 2500 mg/kg bw all of the animals died within 12 hours.