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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2016-03-17 to 2016-04-21
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
ca. 185.2 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
666.67 g/L
Incubation duration:
<= 3 d
Temp.:
20 °C
pH:
ca. 2.4
Water solubility:
ca. 158.8 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
850 g/L
Incubation duration:
<= 3 d
Temp.:
10 °C
pH:
ca. 2.4
Details on results:
Water solubility standard deviation at 10°C: 0.31
Water solubility standard deviation at 20°C: 2.52
A preliminary test was conducted, which showed a water solubility of approx. 250 g/L at 20°C.

The water solubility of the substance was determined in an experimental study under GLP conditions according to OECD Test Guideline 105 by HPLC.

The mean water solubility (3 replicates on three days) was determined at 20°C as 185.2 g/L.

Water solubility at 20°C:

 Equilibration time  measurement 1  measurement 2  measurement 3  mean
 Day 1 187.4  185.9  189.6  187.6
 Day 2 183.4  185.8  178.6 182.6
 Day 3 184.6  189.2  182.4  185.4
          overall mean  185.2
          overall standard deviation

 2.52

Conclusions:
The water solubility of the test item was determined to be 185.2 g/L at 20.0 °C.
Executive summary:

A study was conducted according to OECD Test Guideline 105 using the flask method. The test item was quantified by a validated HPLC method. The mean water solubility (3 replicates over three days) was determined at 20°C as 185.2 g/L and at 10°C as 158.8 g/L. The mean pH of the solutions was 2.4.

Description of key information

The water solubility of the test item was determined to be 185.2 g/L at 20.0 °C (reference 4.8-1).

Key value for chemical safety assessment

Water solubility:
185.2 g/L
at the temperature of:
20 °C

Additional information

A study was conducted according to OECD Test Guideline 105 using the flask method. The test item was quantified by a validated HPLC method. The mean water solubility (3 replicates over three days) was determined at 20°C as 185.2 g/L and at 10°C as 158.8 g/L. The mean pH of the solutions was 2.4.