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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2017-03-22 to 2017-04-04
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
differential scanning calorimetry
Test material information:
Composition 1
Key result
Melting / freezing pt.:
125.13 °C
Atm. press.:
1 013.25 hPa
Decomposition:
yes
Decomp. temp.:
216.36 °C

Based on the observations of the pre-test, the first event (endotherm) was indicated as melting point and the second event was indicated as decomposition of the test item evaluated with event marker function. It was visually determined that the first endothermic effect in the DSC measurement is the melting point of the test item and not the dehydratisation.

Pre-test results for the melting point

Performances

Temperature in °C

Time

Capillary with test item was set in an Aluminium block

20.2

10:46 h

Melting began to a clear colourless liquid

127.4

11:00 h 

Melting ended

143.8

11:03 h

After cooling down: no more residue in the capillary was visible

For the calculation of the mean and the standard deviation all three determinations were taken into account.

Melting point

in °C

in K

1. Determination

125.27

298.42

2. Determination

124.98

298.13

3. Determination

125.15

298.30

Mean

125.13

298.28

Standard Deviation

0.15

0.15

Decomposition

in °C

in K

1. Determination

216.45

489.60

2. Determination

216.12

489.27

3. Determination

216.51

489.66

Mean

216.36

489.51

Standard Deviation

0.21

0.21

Conclusions:
The melting point of the test item was determined to be 125.13 ± 0.15 °C at 1013.25 hPa and the decomposition point was determined to be 216.36 ± 0.21 °C (mean of three determinations).
Executive summary:

A study was conducted according to OECD TG 102 andRegulation (EC) No 440/2008method A.1 to determine the melting point of the test item (reference 4.2-1). The melting point was determined via DSC. In all runs two events were detected.

The first endothermic event was considered as the melting point as 125.13 ± 0.15 °C (398.28 ± 0.15 K) at pressure of 1013.25 hPa. These values are the means of three independent determinations. The second event was indicated as decomposition of the test item at 216.36 ± 0.21 °C (489.51 ± 0.21 K). No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.

Description of key information

The melting point of the test item was determined to be 125.13 ± 0.15 °C at 1013.25 hPa and the decomposition point was determined to be 216.36 ± 0.21 °C (mean of three determinations).

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
125.13 °C

Additional information

A study was conducted according to OECD TG 102 andRegulation (EC) No 440/2008 method A.1 to determine the melting point of the test item (reference 4.2-1). The melting point was determined via DSC. In all runs two events were detected.

The first endothermic event was considered as the melting point as 125.13 ± 0.15 °C (398.28 ± 0.15 K) at pressure of 1013.25 hPa. These values are the means of three independent determinations. The second event was indicated as decomposition of the test item at 216.36 ± 0.21 °C (489.51 ± 0.21 K). No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.