Metam-sodium

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

data from handbook or collection of data

Data source

Reference

Reference 1

Reference Type:

other: Authoritative database

Title:

Toxicological Study of Metam-Sodium (CAS No: 137-42-8)

Author:

HSDB

Year:

2018

Bibliographic source:

U.S. National Library of Medicine National Institutes of Health, Health & Human Services; 2018

Reference 2

Reference Type:

secondary source

Title:

IUCLID Dataset for CAS No: 137-42-8

Author:

EUROPEAN COMMISSION – European Chemicals Bureau

Year:

2000

Bibliographic source:

IUCLID Dataset; EUROPEAN COMMISSION – European Chemicals Bureau; 18–FEB–2000

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

An eye irritation study was conducted for test chemical Metam-sodium (CAS no: 137-42-8) on the six New Zealand White rabbits to determine its eye irritational efficacy.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Metam-sodium

EC Number:

205-293-0

EC Name:

Metam-sodium

Cas Number:

137-42-8

Molecular formula:

C2H5NS2.Na

IUPAC Name:

sodium (methylcarbamothioyl)sulfanide

Test material form:

solid

Specific details on test material used for the study:

- Name of test material : Metam-sodium
- Common name: Sodium methyldithiocarbamate
- Molecular formula : C2H4NNaS2
- Molecular weight : 129.1826 g/mol
- Smiles notation : C(=S)(NC)[S-].[Na+]
- InChl : 1S/C2H5NS2.Na/c1-3-2(4)5;/h1H3,(H2,3,4,5);/q;+1/p-1
- Substance type: Organic
- Physical state: Solid

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Details on test animals or tissues and environmental conditions:

Not specified

Test system

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

100% (Undiluted )

Duration of treatment / exposure:

96 hours

Observation period (in vivo):

after 1, 2, 4, 24, 48, 72, and 96 hours

Number of animals or in vitro replicates:

6 (3/sex)

Details on study design:

- Area of exposure: the conjunctival sac of the right eyelid

SCORING SYSTEM: according to DRAIZE

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 96 h

Reversibility:

not specified

Remarks on result:

positive indication of irritation

Irritant / corrosive response data:

Eye irritation was observed in treated rabbits.

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritating to eyes) based on GHS criteria

Conclusions:

The test material Metam-sodium (CAS no: 137-42-8) was considered to be irritating to the eyes of six New Zealand White rabbits.

Executive summary:

An acute eye irritation study was conducted on six New Zealand White rabbits to assess the eye irritation potential of chemical Metam-sodium (CAS no: 137-42-8).

 

The undiluted chemical was instilled into the conjunctival sac of the right eyelid of 3 male and 3 female NZW-rabbits. After application the eyelids were closed for 1 second and results were read after 1, 2, 4, 24, 48, 72, and 96 hours after application according to Draize method.

 

The treated rabbits showed ocular irritation reactions, hence the test chemical Metam-sodium (CAS no: 137-42-8) was considered to be irritating to the eyes of rabbits.