Registration Dossier

Administrative data

Description of key information

A dermal study with 6 rabbits was performed equivalently to current OECD guidelines.  An eye irritation study was performed, based on these results this substance is not classified for eye irritation.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

A dermal irritation study with 6 rabbits was performed equivalently to current OECD guidelines. At 48 hrs. after removal of the substance, very slight erythema was observed in one rabbit. Since only minor effects were observed in only one of six animals, the substance is not irritating according to CLP Regulation (EC) No 1272/2008.

An eye irritation test similar to the current OECD guideline was performed with 6 rabbits. The suspension of succinonitrile in water (50%) caused slight redness of the conjunctivae in two out of six rabbits. These effects were reversible within 7 days. Based on these results this substance is not classified for eye irritation.

Justification for classification or non-classification

Based on this dermal irritation study the substance is not irritating according to CLP Regulation (EC) No 1272/2008.

An eye irritation test similar to the current OECD guideline was performed with rabbits. The substance was applied 50% diluted and gave minor, reversible effects. Based on these results this substance is not classified for eye irritation.