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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
not specified
Type of method:
flask method
Test material information:
Composition 1
Key result
Water solubility:
ca. 119.9 g/L
Conc. based on:
test mat.
Incubation duration:
> 24 - 72 h
Temp.:
20 °C
pH:
ca. 5.4
Details on results:
The result of the preliminary test: Sample mass: 0.11 g

The result of Water Solubility: 119.9 g/L pH =5.4 20°C.

Table 8 The result of Water Solubility

 No.  Solution  Mass taken (g)  pH at 20°C  Peak area  Average value of peak areas  Factor (f) Average value of f   Mass concentration (g/ml, 20°C)
 1 STD1   0.1221  /  782.43719  /  6.4127E+05  /  /
 2     SMP1     /     5.4  778.20648     778.99954     /  6.4171E+05        1.214E-01
 3  779.79260
 4  STD2  0.1074  /  689.18903  /  6.4215E+05  /  /
 5     SMP2     /     5.4  780 .08844     780.61042     /     6.4605E+05     1.208E-01
 6  781.13239
 7 STD1   0.1221  /  793.02759  /  6.4995E+05  /  /
 8     SMP3     /     5.4  773.50995     776.49945     /     6.6057E+05     1.175E-01
 9  779.48895
 10   STD2  0.1074  /  720.35925  /  6.712E+05  /  /

The relative difference of the concentrations measured in the three flasks respectively:

A—B, 0.5 %; A-C, 3.2%; B-C, 2.8 %.

Conclusions:
The concentrations measured in the three flasks do not differ by more than 15% each other,
the test is satisfactory and the average value of all results can be calculated as the water
solubility.
The last result of water solubility is the mean of the concentrations measured in the three
flasks: [(1.214+1.208+1.175)><10'1/3] g/mL =119.9 g/L, and pH =5.4o
Executive summary:

The water solubility is determined according to “Flask Method” in “OECD 105 WaterSolubility”. Excessive sample is put in water at 30 °C, when saturation is achieved, the mixture is cooled and kept at 20°C. The mass concentration of a.i. in the sample in the aqueous solution, is be determined by GC method. The concentrations measured in the three flasks do not differ by more than 15% each other, the test is satisfactory and the average value of all results can be calculated as the water solubility.

The last result of water solubility is the mean of the concentrations measured in the three flasks: [(1.214+1.208+1.175)><10'1/3] g/mL =119.9 g/L, and pH =5.4

Description of key information

The water solubility of succinonitrile is 119.9 g/L at 20°C and pH 5.4.

Key value for chemical safety assessment

Water solubility:
119.9 g/L
at the temperature of:
20 °C

Additional information

Key information was derived from a test study according to the OECD 105 test guidline