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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation, other
Type of information:
experimental study
Remarks:
polyfluorocarbons
Adequacy of study:
other information
Study period:
1996
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Toxicology of Chlorofluorocarbon Replacements
Author:
Wolfgang Dekant
Year:
1996
Bibliographic source:
Environmental Health Perspectives - Vol 04, Supplement - March 1996

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The publication used is a review for characterisation of toxicological and ecotoxicological effect of CFC (Chlorofluorocarbons) in view of their replacement. No detail on the method used for assessing skin corrosion is provided in the report.
GLP compliance:
not specified

Test material

Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
The publication consider Chlorofluorocarbons coumpounds as a group of substance. Compounds investigated regarding skin irritation are the following :
- 1,1-dichloro-1-fluoroethane [HCFC-141b]
- 1,1,1,2-tetrafluoroethane [HFC-134a],
- pentafluoroethane [HFC-125],
- 1-chloro-1,2,2,2-tetrafluoroethane [HCFC-124],
- 1,1-dichloro-2,2,2-trifluoroethane [HCFC-123]

No additionnal information (regarding the source, purity, condition of storage, treatment prior to testing, etc) are provided.

Results and discussion

In vivo

Irritant / corrosive response data:
Low potential for eye irritation.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
All chlorofluorocarbons compounds investigated (1,1-dichloro-1-fluoroethane [HCFC-141bl, 1,1,1,2-tetrafluoroethane [HFC-134a], pentafluoroethane [HFC-1251, 1-chloro-1,2,2,2-tetrafluoroethane [HCFC-1241, and 1,1-dichloro-2,2,2-trifluoroethane [HCFC-1231) show only a low potential for skin and eye irritation.
Executive summary:

In a published review for characterisation of toxicological and ecotoxicological effect of CFC (Chlorofluorocarbons) in view of their replacement, information are provided on potential for skin and eye irritation of chlorofluorocarbons compounds (CFCs). All CFCs investigated (1,1-dichloro-1-fluoroethane [HCFC-141b], 1,1,1,2 -tetrafluoroethane [HFC-134a], pentafluoroethane [HFC-125], 1 -chloro-1,2,2,2 -tetrafluoroethane [HCFC-124], and 1,1 -dichloro-2,2,2 -trifluoroethane [HCFC-123]) show only a low potential for skin and eye irritation. No detail on the method used for assessing skin corrosion is provided in the report.