Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 200-866-1 | CAS number: 75-37-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The substance is only slightly soluble in blood and tissue as evidenced by the partition coefficients of 1.69 for blood:air, 1.69 for liver:air, 5.63 for fat:air, and 1.47 for muscle:air. The substance would be poorly taken up into the blood following inhalation, and would not tend to accumulate in organs or tissues. The substance that is absorbed will be eliminated primarily by exhalation, without biotransformation or degradation. The small amount of substance that is metabolized proceeds through an oxidative route starting with the carbon-hydrogen bond on the -CHF2 carbon. The likely end-product of metabolism is acetic acid. The metabolism pathway is slow and was demonstrated to saturate at 75000 ppm.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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