Registration Dossier

Administrative data

Description of key information

In - vivo testing on skin sensitisation of Guanidine Thiocyanate is not necessary, due to its corrosive properties.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

According to REACH Regulation Annex VII, column 2, in - vivo testing on skin sensitisation of Guanidine Thiocyanate is not necessary, due to its corrosive properties.

Generally it is assumed that Guanidine Thiocyanate dissociates in aqueous media in the corresponding ions Guanidinium and Thiocyanate. Therefore both ions, independently of its source, can be considered relevant for assessment of skin sensitisation potential.

Thus theoretically salts of both ions with a relatively nontoxic counter ion are suitable to assess the skin sensitizing potential of Guanidine Thiocyanate. Available data from Guanidine nitrate and Guanidine hydrochloride were evaluated for sensitising properties.

In dermal sensitization studies using the method of Buehler sensitization rates at 24 h and at 48 h were 0 % for both Guanidine nitrate and Guanidine hydrochloride.

Further Sodium thiocyanate is reported not to be a dermal sensitizer based on the results of a Local Lymph Node Assay on the ECHA homepage. 

Taken together there is no evidence for a skin sensitising potential of Guanidine Thiocyanate from supporting information of related read-across substances.  

In conclusion it is justified to regard Guanidine Thiocyanate as a non-sensitizer.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on results from Guanidine nitrate, Guanidine hydrochloride and information for

Sodium thiocyanate, it is reasonable to conclude that no classification according to CLP criteria for skin sensitisation of Guanidine Thiocyanate is justified.