Glutaric acid

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

other: Expert assessment

Adequacy of study:

weight of evidence

Study period:

12 January 2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: An assessment was performed based on QSAR ToolBox predictions supported by literature data on the registered substance and analogous substances.

Qualifier:

no guideline required

Version / remarks:

Expert assessment

Principles of method if other than guideline:

An assessment was performed based on QSAR ToolBox 3.3.5.17 predictions supported by literature data on the registered substance and analogous substances.

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

120 mg/L

Nominal / measured:

estimated

Reported statistics and error estimates:

Prediction range: 1.36 - 1.06E+04 mg/L (95% confidence)
Fisher function = 24.1
Fisher threshold for statistical significance (95.0%) confidence = 6.09

Validity criteria fulfilled:

yes

Conclusions:

An expert assessment was conducted which analysed available experimental data and QSAR predictions for the short term toxicity of glutaric acid to fish. The (96h) LC50 was determined to be 120 mg/L for the species Brachydanio rerio, therefore glutaric acid is not considered to be acutely toxic to fish.

Executive summary:

An expert assessment was conducted to determine the short term aquatic toxicity of glutaric acid to fish. A literature search was conducted which identified available data for the substance and its analogous substances (adipic acid, succinic acid, and carboxylic acids, di-, C4-6). The OECD QSAR Toolbox for Grouping Chemicals into Categories was used to form an acute aquatic toxicity endpoint prediction for selected species of fish recommended for freshwater testing according to OECD Guideline 203. All available data and statistically significant QSAR predicitions found the LC50 to be > 100 mg/L. A definitive endpoint can be taken from the lowest predicted value which is (96h) LC50 = 120 mg/L for the fish species Brachydanio rerio. In conclusion, this expert assessment determines that glutaric acid is not considered to be acutely toxic to fish.

Description of key information

An expert assessment was conducted which determined the (96h) LC50 to be 120 mg/L for the fish species Brachydanio rerio, therefore glutaric acid is not considered to be acutely toxic to fish.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

120 mg/L

Additional information

An expert assessment was conducted to determine the short term aquatic toxicity of glutaric acid to fish. A literature search was conducted which identified available data for the substance and its analogous substances (adipic acid, succinic acid, and carboxylic acids, di-, C4-6). The OECD QSAR Toolbox for Grouping Chemicals into Categories was used to form an acute aquatic toxicity endpoint prediction for selected species of fish recommended for freshwater testing according to OECD Guideline 203. All available data and statistically significant QSAR predicitions found the LC50 to be > 100 mg/L. A definitive endpoint can be taken from the lowest predicted value which is (96h) LC50 = 120 mg/L for the fish species Brachydanio rerio. In conclusion, this expert assessment determines that glutaric acid is not considered to be acutely toxic to fish.