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EC number: 203-907-1
CAS number: 111-78-4
no further remarks
In this in vivo rat micronucleus test 10 male rats were exposed for 6
hours/day for 2 consecutive days to 1500 ppm 1,5-cyclooctadiene.
5 male rats were exposed to the negative control (air). Bone marrow
polychromatic erythrocytes, collected 24 hours after the last
exposure, were examined microscopically for micronucleated polychromatic
No statistically significant increase in the frequency of
micronucleated PCE's was observed in treated rats. A statistically
significant depression in the proportion of PCEs among 1000 erythrocytes was observed in the treatment group, indicative
of testsubstance-induced bone marrow toxicity. A statistically significant increase in MNPCE frequency was found in the positive
Under the conditions of this in vivo study 1,5-cyclooctadiene did not
induce micronucleated polychromatic erythrocytes in male rats.
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