Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Adequacy of study:
other information
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Precursors of carcinogenic hydrocarbons in tobacco smoke.
Author:
Gil-Av E and Shabtai J
Year:
1963
Bibliographic source:
Nature 197, 1065-1066. |cited in: Patty's 4th Edition, Volume II, Part B, page 1284.

Materials and methods

Objective of study:
metabolism

Test material

Constituent 1
Chemical structure
Reference substance name:
Cycloocta-1,5-diene
EC Number:
203-907-1
EC Name:
Cycloocta-1,5-diene
Cas Number:
111-78-4
Molecular formula:
C8H12
IUPAC Name:
(1Z,5Z)-cycloocta-1,5-diene

Results and discussion

Applicant's summary and conclusion

Conclusions:
1,5-Cyclooctadiene is metabolized in rabbits and rats to dihydroxycyclooctyl mercapturic acid and to sulfate and glucuronide conjugates.