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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07-17 December 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified with purity. Therefore full validation applies.
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. certificate)
Remarks:
inspected on January 22 and 23, 2013 / signed on March 22, 2013
Type of method:
effusion method: Knudsen cell
Specific details on test material used for the study:
Storage condition of test material: 11-25°C, dry, keep container closed
Key result
Temp.:
20 °C
Vapour pressure:
0.024 Pa
Remarks on result:
other: extrapolated
Temp.:
25 °C
Vapour pressure:
0.041 Pa
Remarks on result:
other: extrapolated
Temp.:
50 °C
Vapour pressure:
0.49 Pa
Remarks on result:
other: interpolated

Thermal Stability:

No thermal effects could be observed up to the maximum test temperature of 300 °C.

 

Effusion method: Knudsen cell

The vapour pressure was measured in the temperature range of 35 to 66 °C.

 

Table 4.6/1: Results of the Effusion method

No.

Temperature (°C)

Evaporation rate (kg/s)

Vapour pressure (Pa)

1

35

3.99 x 10-10

0.13

2

40

5.95 x 10-10

0.20

3

46

9.07 x 10-10

0.31

4

51

1.45 x 10-9

0.49

5

56

2.23 x 10-9

0.76

6

61

3.61 x 10-9

1.24*

7

66

6.21 x 10-9

2.16*

 

*Two values are slightly outside but very close to the recommended pressure range for the apparatus used (10-3 to 1 Pa). Considering that the vapour pressures measured are inside (or very close to) the applicability domain of the method and given the good linearity of the measurements, the results are considered as valid.

Regression parameters are: log10 P = 12.5416 - (4153.31 / T)

R2 = 0.995

with P in Pa and T in K

 

The vapour pressure of the test item calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C were 2.4 x 10-2 (extrapolated), 4.1 x 10-2 (extrapolated) and 4.9 x 10 -1 (interpolated) Pa, respectively.

 

Considering that the vapour pressures measured are inside (or very close to) the applicability domain of the method and given the good linearity of the measurements, the results are considered as valid.

Conclusions:
Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), < 500 Pa).
Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline by an effusion method: Knudsen cell.

No thermal effects could be observed up to the maximum test temperature of 300 °C.

Seven measurements were performed in the temperature range of 35-66 °C.

The vapour pressure of the test item calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C were 2.4 x 10-2 (extrapolated), 4.1 x 10 -2 (extrapolated) and 4.9 x 10 -1 (interpolated) Pa, respectively.

Description of key information

Low volatility.

Key value for chemical safety assessment

Vapour pressure:
0.041 Pa
at the temperature of:
25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EU method, and under GLP, is available. It is considered as a key study. The result is retained as key data.