Registration Dossier

Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
genetic toxicity in vivo
Remarks:
Type of genotoxicity: other: QSAR method
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Regulatory accepted QSAR method for organic chemicals properties assessment.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: QSAR method
Principles of method if other than guideline:
QSAR method: Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES
GLP compliance:
no
Remarks:
not applicable to QSAR models
Type of assay:
other: QSAR method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Conclusions:
Available QSAR methods does not identify styrene as genotoxic/non-genotoxic mutagen.