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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
publication
Title:
Toxicological studies of certain alkylated benzenes and benzene: Experiments on laboratory animals.
Author:
Wolf et al.
Year:
1956
Bibliographic source:
AMA Arch Ind Health Vol.14 (4): 387-398.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Subchronic Oral Toxicity Study (Repeated Exposure)
Principles of method if other than guideline:
Subchronic Oral Toxicity Study (Repeated Exposure)
Study investigated: repeated toxicity of styrene to rats via oral administration
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Study Observed:

At ≥400 mg/kg bw/day: slight to moderate growth depression, slight to moderate effects on liver and kidney weights

LOEL (NOAEL) (rats, oral, 6-month) =400 mg/kg bw/day (effects on body weights, effects on liver & kidney weights) [NOEL =133 mg/kg bw/day]

Applicant's summary and conclusion

Conclusions:
The following No Observed Adverse effect levels could be identified from this study:
LOEL (NOAEL) (rats, oral, 6-month) =400 mg/kg bw/day (effects on body weights, effects on liver & kidney weights) [NOEL =133 mg/kg bw/day]