Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
publication
Title:
Toxicological studies of certain alkylated benzenes and benzene: Experiments on laboratory animals.
Author:
Wolf et al.
Year:
1956
Bibliographic source:
AMA Arch Ind Health Vol.14 (4): 387-398.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Eye Irritation Study
Principles of method if other than guideline:
Study investigated: eye irritation of styrene to rabbits on single eye contact
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Study Observed:

Styrene exposure resulted in moderate conjunctival irritation (inflammation and slight swelling of the eyelids) and slight, transient corneal injury (perceptible superficial necrosis involving less than 50% of the cornea).

Applicant's summary and conclusion

Conclusions:
Styrene was irriating when applied to rabbits eyes.