Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
publication
Title:
Toxicological studies of certain alkylated benzenes and benzene: Experiments on laboratory animals.
Author:
Wolf et al.
Year:
1956
Bibliographic source:
AMA Arch Ind Health Vol.14 (4): 387-398.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Skin Irritation and Absorption Study
Principles of method if other than guideline:
Skin Irritation and Absorption Study
Study investigated: skin irritation and absorption of styrene to rabbits on repeated skin contact
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Study Observed:

Styrene exposure resulted in moderate skin irritation (definite erythema) as well as slight necrosis (development of a thin layer of devitalized tissue which resulted in exfoliation).

Study authors concluded that there was no indication that the substance was absorbed through the skin in acutely toxic amounts (as judged by the gross appearance, behavior and body weights of animals) during the repeated-exposure skin irritation tests.

Applicant's summary and conclusion

Conclusions:
Styrene caused moderate skin irritation when applied undiluted in rabbits.