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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
publication
Title:
Concentrations of hydrocarbons in tissues as a measure of toxicity.
Author:
Shugaev
Year:
1969
Bibliographic source:
Arch Environ Health. Vol. 18: 878-882.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
Acute Inhalation Toxicity Study (Single Exposure)
Study investigated: lethal concentrations of styrene in rats and mice
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Study Observed:

 

 LC50 (inhalation, mice, 2-hour) =21.0 mg/L.

 LC50 (inhalation, rats, 4-hour) =11.8 mg/L.

Applicant's summary and conclusion

Conclusions:
The cut-off value for classification of substances for acute inhalation toxicity for vapours is LC50= 20 mg/L. The published data for styrene report LC50 value for rat lower than 20 mg/L.
In addition, styrene has harmonized at EU level classification and it is classified as Xn; R20 – Harmful by inhalation, in accordance with Directive 67/548/EEC, and Acute Toxicity, Hazard Category 4, H332: Harmful if inhalled, in accordance with the GHS criteria of Regulation (EC) No 1272/2008.
It is, therefore, considered that styrene is of moderate acute toxicity in experimental animals by inhalation.