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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
publication
Title:
Toxicological studies of certain alkylated benzenes and benzene: Experiments on laboratory animals.
Author:
Wolf et al.
Year:
1956
Bibliographic source:
AMA Arch Ind Health Vol.14 (4): 387-398.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Study investigated: acute toxicity of styrene to rats via oral administration
GLP compliance:
not specified
Test type:
other: acute oral toxicity study

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Study Observed:

 

LD50 (rats, oral)= approx. 5000 mg/kg bw

Applicant's summary and conclusion

Conclusions:
Acute oral toxicity of styrene in rats was reported as follows: LD50 (oral, rats)= approx. 5000 mg/kg bw