Registration Dossier

Toxicological information

Dermal absorption

Currently viewing:

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
publication
Title:
Dermal Absorption of Organic Chemical Vapors in Rats and Humans.
Author:
McDougal et al.
Year:
1990
Bibliographic source:
Fundamental and Applied Toxicology, Vol. 14: 299 -308.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: skin absorption study
Principles of method if other than guideline:
Study investigated: the dermal penetration of styrene vapour via rats skin (in vivo study).
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: vapour
Radiolabelling:
yes

Results and discussion

Any other information on results incl. tables

Study observed:

Skin permeability constant: 1.75 cm/hr

Skin uptake of styrene in a mixed exposure (through the respiratory tract and through the skin): 9.4% of the total uptake.

Applicant's summary and conclusion

Conclusions:
Skin uptake of vapour styrene in rats was reported to be low.