Registration Dossier

Administrative data

Endpoint:
long-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Regulatory accepted QSAR method for organic chemicals properties assessment.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: QSAR method
Principles of method if other than guideline:
QSAR method: ECOSAR Program (v1.00)
GLP compliance:
no
Remarks:
not applicable to QSAR models

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test organisms

Test organisms (species):
other: fish

Study design

Test type:
other: QSAR method

Results and discussion

Any other information on results incl. tables

Overview of QSARs estimations on long-term aquatic toxicity of styrene to fish

Method

 

Results

Remarks

Reference

QSAR

estimate

Fish, 14-day LC50 =13.432 mg/L (ppm)

 

Fish, 30-day, ChV (chronic value) =1.448 mg/L (ppm)

 

Fish (SW), ChV (chronic value) =3.190 mg/L (ppm)

 

Reliable with

restrictions,

QSAR estimated

data

ECOSAR

Program

(v1.00)

Applicant's summary and conclusion

Conclusions:
The QSAR estimated data on long-term aquatic toxicity of styrene to fish is summarised as follows:
Fish, 14-day LC50 =13.432 mg/L (ppm)
Fish, 30-day, ChV (chronic value) =1.448 mg/L (ppm)
Fish (SW), ChV (chronic value) =3.190 mg/L (ppm)