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EC number: 233-059-8 | CAS number: 10026-12-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Publication with a significant methodological deficiency. Only 1 mg of the test item was used. The guideline is recommending, that the dose should be 0.1 mL or 100 mg
Data source
Reference
- Reference Type:
- publication
- Title:
- Pharmacology and Toxicology of Niobium Chloride
- Author:
- Haley T.J., Komesu N., and Raymond K.
- Year:
- 1 962
- Bibliographic source:
- Toxicology and Applied Pharmacology 4: 385-392
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Principles of method if other than guideline:
- 1 mg of the test item was used. The guideline is recommending, that the dose should be 0.1 mL or 100 mg
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Niobium pentachloride
- EC Number:
- 233-059-8
- EC Name:
- Niobium pentachloride
- Cas Number:
- 10026-12-7
- Molecular formula:
- Cl5Nb
- IUPAC Name:
- Niobium(V) chloride
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Niobium pentachloride
- Analytical purity: 99.5%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1 mg - Duration of treatment / exposure:
- According to the method of Draize et al. (1944)
- Observation period (in vivo):
- According to the method of Draize et al. (1944)
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- According to the method of Draize et al. (1944). Three rabbits had 1 mg of niobium pentachloride placed in one eye while the
other eye served as a control.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Remarks on result:
- other: No evidence of corneal damage, iris damage, conjunctival irritation, chemosis or increased lachrymal fluid
- Irritant / corrosive response data:
- Direct application of 1 mg of niobium pentachloride to the eyes of rabbits resulted in an immediate increase in the rate of blinking and a redness of the palpebral conjunctiva within 1 hour. At 24 hours there was no evidence of corneal damage, iris damage, conjunctival irritation, chemosis, or increased lachrymal fluid.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item did not induce damages to the eye when an amount of 1 mg was applied to the rabbit eye. This amount is not sufficient to conclude on eye irritation properties according to CLP.
- Executive summary:
In a primary eye irritation study according to the method of Draize et al. (1944), 1 mg of niobium pentachloride was placed into one eye of each of three rabbits. Animals then were observed for 24 hours. Only a very mild reaction immediately after application was observed, consisting of blinking and redness of the palpebral conjunctiva. After 24 hours no signs of any eye damage were observed. Under the conditions of the study and the dose applied (1 mg) niobium pentachloride can be considered as not eye irritating. This result has been disregarded as the small amount of the test item applied (1 mg) is not sufficient for CLP classification. According to OECD guideline 405 requirements, 100 mg of the test item needs to be applied. Thus, it can only be concluded that the puffer capacity of the lachrymal fluid is high enough to neutralize small amounts (1 mg) of the test item. Based on the study results it is not possible to derive a classification according to CLP. Due to the classification of NbCl5 as skin corrosive Cat 1B, severe eye damages would be expected if higher amounts of the test item would be applied to the eye.
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