Registration Dossier
Registration Dossier
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EC number: 244-838-7 | CAS number: 22204-53-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Year:
- 2 009
- Bibliographic source:
- American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD (2009), p.2169 (HSDB data base)
Materials and methods
- Principles of method if other than guideline:
- Method not published
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Naproxen
- EC Number:
- 244-838-7
- EC Name:
- Naproxen
- Cas Number:
- 22204-53-1
- Molecular formula:
- C14H14O3
- IUPAC Name:
- naproxen
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 534 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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