Registration Dossier
Registration Dossier
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EC number: 613-739-4 | CAS number: 65039-09-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- NTP Report on the Assessment fo Contact Hypersensitivity to 1-Ethyl-3-Methylimidazolium Chloride in Female BALB/c Mice
- Author:
- NTP-National Toxicology Program
- Year:
- 2 010
- Bibliographic source:
- NTP Report Number I07018
Materials and methods
- Principles of method if other than guideline:
- Combined local lymph node assay (LLNA) and irritancy assay (IRR)
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 1-Ethyl-3-Methylimidazolium Chloride
- IUPAC Name:
- 1-Ethyl-3-Methylimidazolium Chloride
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 6.25; 12.5; 25 and 50 %
Results and discussion
Any other information on results incl. tables
In teh LLNA, EMI at concentrations of 6.25 - 50% did not induce significant increases in lymph nde cell proliferation when compared to the vehicle control. In addition, EMI was not an irritant at concentrations up to 50%, as demonstrated by a lack of effect on ear thickness at 24 hr following the last dermal exposure.
Applicant's summary and conclusion
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