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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
no glp, no guideline available (older than guideline and glp) water from lakes was used for experiment; In 1972 water from lakes contained high amounts of chelating agent (e.h. EDTA) Chelating agent stabilze Sn(II) and avoid the formation of hydroxide. So the amount of Sn(II) in water in the study measured is higher than the solubility of Sn(II) at this pH.(see discussion in endpoint summary Environmental fate and pathways)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
Deviations:
not applicable
Principles of method if other than guideline:
For chronic studies five daphnia 12 +/- 12 hr old were placed in 200 ml water in a 250 ml beaker. Four beakers (the test chambers) were used with total 20 animals for each experimental and control condition for each test. The test chambers were covered with a pane glase to minimize evaporation, and distributed randomly on a shelf in a constant temperature (18°C +/- 1) Young daphnia were placed in the test chambers, transfered into a new medium at the beginning of each week with a medicine dropper, an subjected to test conditions for 3 wks. Survival of the initial animals was noted after 1, 2 and 3 wks. At the end of the week 3 the survival animals was weighed and prepared for protein and GOT analyses. Reproduction was accessed by counting the young produced every week; the young was counted and discarded each time the inital animals were transfered and at the end of each experiment
GLP compliance:
no
Analytical monitoring:
yes
Vehicle:
no
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
3 wk
Duration:
3 wk
Dose descriptor:
other: Chronic, 16% reproductive impairment
Effect conc.:
0.35 mg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
reproduction
Remarks on result:
other: value for Sn2+
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.18 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
dissolved
Remarks:
Sn
Basis for effect:
reproduction
Validity criteria fulfilled:
yes
Conclusions:
The value for 16% reproductive impairment was determinated to be 0.35 mg Sn^{+2} /L = 0.63 mg SnSO_4 / L

NOEC(21d)=0.18 Sn^{+2} mg/L = 0.32 mg SnSO_4 / L

Description of key information

Daphnia magna, NOEC(21d)=0.18 Sn^{+2} mg/L = 0.32 mg SnSO_4 / L

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
NOEC
Effect concentration:
0.32 mg/L

Additional information