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Information regarding the lethal toxicity of iron pentacarbonyl is limited to statements by Stokinger (1994) that death may occur 4-11 days following exposure (exposure terms not provided). Pathologic findings may include pulmonary hepatization, vascular injury, and degeneration of the central nervous system. No further details are available regarding these qualitative descriptions.

Information on the nonlethal toxicity of iron pentacarbonyl in humans is limited to qualitative descriptions provided by Stokinger (1994). Stokinger noted that the signs and symptoms of iron pentacarbonyl exposure are similar to those for nickel carbonyl and include giddiness and headache and occasionally dyspnea and vomiting, these effects being similar to those associated with metal fume fever. With the exception of dyspnea, these signs and symptoms are alleviated upon removal from exposure, but fever, cyanosis, and coughing may occur 12-36 h after exposure. No source was provided for validation of this information, and no further details were available.

No epidemiologic studies of iron pentacarbonyl toxicity are available.

Data regarding the reproductive/developmental toxicity of iron pentacarbonyl in humans are not available.

No human genotoxicity data for iron pentacarbonyl are currently available.

Information regarding the potential carcinogenicity of iron pentacarbonyl in humans is not available.

Source: Iron Pentacarbonyl: Acute Exposure Guideline Levels.