Registration Dossier

Administrative data

Endpoint:
neurotoxicity: acute inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic information given, scientifically acceptable
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report Date:
1988

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: EPA OPP 81-3 (acute inhalation toxicity)
GLP compliance:
yes
Remarks:
testing lab.
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Duration of treatment / exposure:
4 h
Doses / concentrations
Remarks:
Doses / Concentrations:
5.2, 17, 28, 60 ppm
Basis:

No. of animals per sex per dose:
5
Control animals:
yes

Examinations

Neurobehavioural examinations performed and frequency:
Neurological examination was performed prior to exposure and at 1 and 4 hours post-exposure.

Results and discussion

Results of examinations

Details on results:
A treatment-related pattern was seen during the first 2 days after exposure at the 3 high levels. The most common finding was flaccidity of body tone on the day after exposure. The 60 ppm animals also showed flaccidity of limb tone, decreased to pinch, righting and startle reflex, and ataxia. The control and 5.2 ppm animals were comparable.

Effect levels

Basis for effect level:
other: see 'Remark'
Remarks on result:
not measured/tested
Remarks:
Effect level not specified

Applicant's summary and conclusion