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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP, non-guideline, animal experimental study, restrictions in design and or reporting but otherwise adequate for assessment

Data source

Reference
Reference Type:
publication
Title:
The acute oral toxicity of acetic, chloroacetic, dichloroacetic and trichloroacetic acids
Author:
Woodard G, Lange SW, Nelson KW and Calvery HO
Year:
1941
Bibliographic source:
J Ind Hyg Toxicol, Vol 23, PP 78-82

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The sodium salt of acetic acid was administered by oral gavage to groups of rats (at a dose rate of approx. 0.1 mL/g bodyweight). The rats were fasted for 18 hours prior to dosing. The animals were observed for 6 days following dosing.
GLP compliance:
no
Test type:
other:
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium acetate
EC Number:
204-823-8
EC Name:
Sodium acetate
Cas Number:
127-09-3
Molecular formula:
C2H4O2.Na
IUPAC Name:
sodium acetate
Details on test material:
- Name of test material (as cited in study report): acetic acid
- Ionisation constant: 1.86 x 10 E-5
- Acetic acid was adjusted with sodium hydroxide, before dosing, to pH between 6 and 7

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Sex: predominantly males
- Age: 70-100 days
- Weight: 150-250 g
- No further details

IN-LIFE DATES: no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
Dose concentration: 0.01 cc/g bw
Doses:
2239, 2512, 2859, 3100, 3500, 4000, 4467 mg/kg
No. of animals per sex per dose:
10, except for 2859 mg/kg group when only 5 were dosed
Control animals:
no
Details on study design:
- Duration of observation period following administration: 6 days
Statistics:
Dose-mortality curves prepared according to the methods of Bliss (Bliss CI. An. Appl. Biol. 22, 134 (1935)) and according to the example described by Laug et al (Laug EP, Calvery HO, Morris HJ and Woodard G, J. Ind. Hyg. Toxicol. 21, 173 (1939)).

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 310 mg/kg bw
Remarks on result:
other: sodium salt of acetic acid
Mortality:
1/10, 0/10, 3/5, 5/10, 6/10, 7/10, 8/10 for 2239, 2512, 2859, 3100, 3500, 4000, 4467 mg/kg respectively.
Clinical signs:
other: No data
Gross pathology:
No data

Applicant's summary and conclusion

Conclusions:
The acute oral LD50 of the sodium salt of acetic acid was 3310 mg/kg bw for rats.
Executive summary:

The acute oral LD50 of the sodium salt of acetic acid was 3310 mg/kg bw for rats.