Registration Dossier
Registration Dossier
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EC number: 231-843-4 | CAS number: 7758-94-3
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication, reasonably documented, acceptable for assessment.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- A concise review: Iron absorption - the mucin-mobilferrin-integrin pathway. A competitive pathway for metal absorption
- Author:
- Conrad ME, Umbreit JN
- Year:
- 1 993
- Bibliographic source:
- American Journal of Hematology 42:67
Materials and methods
- Objective of study:
- absorption
- Principles of method if other than guideline:
- Iron salt species analysed: unclear
Test material
- Reference substance name:
- Iron trichloride
- EC Number:
- 231-729-4
- EC Name:
- Iron trichloride
- Cas Number:
- 7705-08-0
- Molecular formula:
- FeCl3
- IUPAC Name:
- Iron (III) chloride
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Iron is solubilised in the acid pH of the stomach then chelates with proteins which retain the iron in soluble form available for absorption in the higher pHs of the small intestine.
- Type:
- absorption
- Results:
- Proteins on the surface of the absorptive cell facilitate the transfer the iron through the cell membrane into the absorptive cell where it binds with a shuttle protein.
- Type:
- distribution
- Results:
- The mechanism of facilitating transfer of iron into the plasma is not understood.
- Type:
- metabolism
- Results:
- Excess iron in the cell stimulates synthesis of ferritin, and iron is deposited in this storage protein to prevent oxidative damage to the cell.
Any other information on results incl. tables
Justification for read-across
The surrogate material dissociates in physiological pH to the same species produced by the (iron III & II) salts after equilibration. As discussed in the category justification section, such equilibrium is quickly established. In result, iron species burden is assumed to be comparable to equimolar exposure within the iron category member salts.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
