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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1982

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Summary of acute effects of exposure listed in handbook
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): chloroprene; 2-chlorobutadiene-1,3-; ß-chloroprene
- Molecular formula (if other than submission substance): CH2-CClCH-CH2

Test animals

Species:
other: rat and mouse
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not applicable

Administration / exposure

Route of administration:
other: oral , dermal and inhalation results presented
Vehicle:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
146 mg/kg bw
Based on:
test mat.
Remarks on result:
other: LD50 mouse
Sex:
not specified
Dose descriptor:
LD50
Effect level:
450 mg/kg bw
Based on:
test mat.
Remarks on result:
other: LD50 rat
Sex:
not specified
Dose descriptor:
LC50
Effect level:
3 480 other: mg/m3
Based on:
test mat.
Remarks on result:
other: LC 50 mouse
Sex:
not specified
Dose descriptor:
LC50
Effect level:
11 800 other: mg/m3
Based on:
test mat.
Remarks on result:
other: LC 50 rat
Other findings:
intragastric intubation (acute oral) LD50 in mice - 146 mg/kg bw (119-180 fiducial limits)
intragastric intubation (acute oral) LD50 in rat - 450 mg/kg bw (369-550 fiducial limits)

Dermal LD50 in minutes - mouse 78 (57-106); rat 330 (268-406)

Inhalation LC50 mouse 3480 (3000 - 4000) mg/m3 for 2 h exposure; rat 11800 (10500 - 13200) mg/m3 for 4 h exposure

Described as narcotic, affecting internal organs and irritating the upper respiratory tract


Applicant's summary and conclusion

Conclusions:
intragastric intubation (acute oral) LD50 in mice - 146 mg/kg bw (119-180 fiducial limits)
intragastric intubation (acute oral) LD50 in rat - 450 mg/kg bw (369-550 fiducial limits)

Dermal LD50 in minutes - mouse 78 (57-106); rat 330 (268-406)

Inhalation LC50 mouse 3480 (3000 - 4000) mg/m3 for 2 h exposure; rat 11800 (10500 - 13200) mg/m3 for 4 h exposure

Described as narcotic, affecting internal organs and irritating the upper respiratory tract