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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The available study is inadequate for classification of chloroprene in relation to dermal toxicity. Some information from the study report is summarised here to indicate potential dermal absorption and irritation in rabbits.
Justification for data waiving:
other:

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1970
Report Date:
1970

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The sample was applied to the clipped trunk of six male albino rabbits at a single dose level of 200 mg/kg of body weight over a 24 hour period. After exposure, the wrappings were removed and the skin was washed with water. The animals were observed for 48 hours.
GLP compliance:
no
Test type:
other: dermal toxicity study
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Impurities: 1.4% 1,4 Dichlorobutene-1, 0.1% 1,4 dichlorobutene-2 plus stabilisers and inhibitors.

Test animals

Species:
rabbit
Strain:
other: albino
Sex:
male
Details on test animals and environmental conditions:
No further data.

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
The sample, as received was applied to the clipped trunk of six male albino rabbits at a single dose level of 200 mg/kg of body weight. The rabbits were restrained in stocks, and their trunks wrapped loosely with aluminium foil and rubber dam for the 24 hour exposure period. After the exposure, the wrappings were removed and the skin was washed with water. The animals were observed for 48 hours.
Duration of exposure:
24 hour exposure period.
Doses:
One single dose of 200 mg/kg/bw (average dose of 0.67 mL).
No. of animals per sex per dose:
No data.
Control animals:
not specified
Details on study design:
No further information.
Statistics:
No data.

Results and discussion

Preliminary study:
No data.
Mortality:
None of the animals died during the experiment.
Clinical signs:
24 hours - Mild to moderate skin erythema with oedema,
48 hours - Generally mild to moderate skin erythema.
Body weight:
Average body weights (g) - INITIAL = 3231 g and FINAL = 3078 g
Gross pathology:
No data.
Other findings:
No further data.

Any other information on results incl. tables

No data.

Applicant's summary and conclusion

Conclusions:
2-Chloro-1, 3-butadiene does not classify as a Class B poison via the skin absorption route when tested according to the ICC regulations as no deaths occurred when applied at a level of 200 mg/kg of body weight.
Executive summary:

2-Chloro-1, 3-butadiene does not classify as a Class B poison via the skin absorption route when tested according to the ICC regulations as no deaths occurred when applied at a level of 200 mg/kg of body weight.

Insufficient data to draw conclusion related to rabbit dermmal toxicity or levels of irritancy for classification purposes