Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-906-6 | CAS number: 7778-50-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The EU RAR reports the results of a number of studies of different design, however the results are consistent.
Data source
Reference
- Reference Type:
- other: EU RAR
- Title:
- European Union Risk Assessment Report: chromium trioxide, sodium chromate, sodium dichromate, ammonium dichromate, potassium dichromate
- Author:
- European Chemicals Bureau
- Year:
- 2 005
- Bibliographic source:
- 3rd Priority List; Volume 53
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The EU RAR reports the results of a number of eye irritation studies of different design.
- GLP compliance:
- no
- Remarks:
- Published studies: pre-date GLP
Test material
- Reference substance name:
- Sodium chromate
- EC Number:
- 231-889-5
- EC Name:
- Sodium chromate
- Cas Number:
- 7775-11-3
- IUPAC Name:
- disodium dioxido(dioxo)chromium
- Reference substance name:
- Potassium dichromate
- EC Number:
- 231-906-6
- EC Name:
- Potassium dichromate
- Cas Number:
- 7778-50-9
- Molecular formula:
- K2Cr2O7
- IUPAC Name:
- sodium dichromate
- Details on test material:
- The reviewed studies were performed with sodium chromate and potassium dichromate.
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- other: undiluted / neutralised
- Controls:
- no
- Duration of treatment / exposure:
- Various
- Observation period (in vivo):
- Various
- Number of animals or in vitro replicates:
- Not stated
Results and discussion
Any other information on results incl. tables
A single administration of neutralised sodium chromate solution was not irritant to the rabbit eye. I n contrast, repeated administration of potassium dichromate in powder form daily for 7 days caused severe irritation including necrosis of the conjunctivae and ulceration of the cornea.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- It is concluded that the water soluble chromium (VI) compounds are likley to be eye irritants.
- Executive summary:
The results of animal experiments indicate that water-soluble Cr (VI) compounds are likely to be eye irritants as a consequence of their low pH.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
