Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 200-589-6 | CAS number: 64-67-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- no data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The results are not enough detailed to conclude and propose a classification
Data source
Reference
- Reference Type:
- publication
- Title:
- Range finding toxicity data, list III
- Author:
- Smyth HF, Carpenter CP, Weil CS
- Year:
- 1 949
- Bibliographic source:
- J Ind Hyg Tox 31: 60-61
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Similar to the standard guideline except for the number of observations.
More details on the method are given in previous publications. These details have been added hereafter.
The publications are:
Smyth & Carpenter (1944): The place of the range-finding test in the industrial toxicology laboratory. J Ind Hyg Tox 26: 269-273
Smyth & Carpenter (1948): Further experience with the range finding test in the industrial toxicology laboratory. J Ind Hyg Tox 30: 63-68 - GLP compliance:
- no
- Remarks:
- Test performed before the GLP creation
Test material
- Reference substance name:
- Diethyl sulphate
- EC Number:
- 200-589-6
- EC Name:
- Diethyl sulphate
- Cas Number:
- 64-67-5
- Molecular formula:
- C4H10O4S
- IUPAC Name:
- diethyl sulfate
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino, no further data
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.01 mL
VEHICLE: none - Duration of treatment / exposure:
- 24 h
- Observation period:
- 24 h
- Number of animals:
- 5
- Details on study design:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 6
- Max. score:
- 10
- Reversibility:
- no data
- Irritant / corrosive response data:
- According to the criteria showed above, necrosis is produced
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The results are not enough detailed, to propose a conclusion
- Executive summary:
The irritation effects of DES have been studied in a test with 5 rabbits exposed for 24 h to 0.01 mL of the test substance.
The effects were observed at 24 h only. Necrosis was observed (score of 6 on a scale from 1 to 10).
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