Registration Dossier
Registration Dossier
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EC number: 200-589-6 | CAS number: 64-67-5
Endpoint summary
Administrative data
Description of key information
DES is harmful by inhalation and oral route and is toxique by dermal route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 350 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Value:
- mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Value:
- mg/kg bw
Additional information
3 oral LD50 were found in rat: 350; 880 or 1410 mg/kg.
All of them were poorly described so it was not possible to define the most relevant one. The lowest has then been chosen.
A dermal LD50 of 700 mg/kg was obtained in rabbit.
A very old inhalation study gave a LC50 (4h) between 250 and 500 ppm in rat. The validity is poor.
Justification for classification or non-classification
According to these values, a classification as cat 4 for oral acute toxicity, cat 3 for dermal acute toxicity is necessary.
Annex VI classification is: cat 4 for the 3 routes. This cat 4 for inhalation can be kept.
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