Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
Reference is included as supportive information for animal testing results. Not directly useable for hazard classification purposes

Data source

Reference
Reference Type:
publication
Title:
Chemical burns of the human cornea
Author:
McLaughlin RS
Year:
1946
Bibliographic source:
Am J Opthamology 29, p1355-62.

Materials and methods

Study type:
clinical case study
Endpoint addressed:
eye irritation
Test guideline
Qualifier:
no guideline required

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Method

Type of population:
not specified
Subjects:
Publication contains extracts from case reports covering a three year period of chemical burns to the eye treated by the author. Single report of case involving methoxyethanol (methyl ‘Cellosolve’) where prompt healing was reported to have occurred within 48 hours following the author’s recommended first aid treatment. First aid treatment was long flushing with water followed by treatment as required by an opthalmologist within 2 hours of exposure and denudation.
Route of exposure:
ocular
Reason of exposure:
accidental

Results and discussion

Results of examinations:
Healing occured within 48 hours,

Applicant's summary and conclusion

Executive summary:

A case history of human eye exposure to 2 -methoxyethanol showed that prompt healing occured within 48 hours, suggesting that human eye irritancy potential is low.