2-ethoxyethanol

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable publication

Data source

Reference

Reference Type:

publication

Title:

The Toxicity of Butyl Cellosolve Solvent

Author:

Carpenter, C.P. et al.

Year:

1956

Bibliographic source:

Arch. Ind. Health 14, 114-131

Materials and methods

Principles of method if other than guideline:

other: Acute intravenous and intraperitoneal toxicity

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-ethoxyethanol

EC Number:

203-804-1

EC Name:

2-ethoxyethanol

Cas Number:

110-80-5

Molecular formula:

C4H10O2

IUPAC Name:

2-ethoxyethan-1-ol

Details on test material:

Name of the test substance as stated in the publication: "Cellosolve"

Test animals

Species:

rat

Strain:

not specified

Sex:

female

Administration / exposure

Route of administration:

other: intravenous and intraperitoneal

Vehicle:

other: NaCl solution (0.75 %) for intravenious injection

Doses:

undiluted; 0.18 % in 0.75 % NaCl

Results and discussion

Effect levels

Effect levels 1

Sex:

female

Dose descriptor:

LD50

Effect level:

2.38 mL/kg bw

Based on:

test mat.

Remarks on result:

other: undiluted; range 1.92 to 2.97 mL/kg; the LD50 value is equal to 2187 mg/kg with a density of 0.919 at 25 °C

Effect levels 2

Sex:

female

Dose descriptor:

LD50

Effect level:

3 250 mg/kg bw

Remarks on result:

other: 18 % of test substance in 0.75 % NaCl; range 2480 to 4260 mg/kg

Effect levels 3

Sex:

female

Dose descriptor:

LD50

Effect level:

2.14 mL/kg bw

Remarks on result:

other: intraperitoneal; range (1.54 to 2.99 mL/kg); value corresponds to 1966 mg/kg with a density of 0.919 at 25 °C