Registration Dossier
Registration Dossier
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EC number: 203-804-1 | CAS number: 110-80-5
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity: acute oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative immunosuppression of various glycol ethers orally administered to Fischer 344 rats
- Author:
- Smialowrcz RJ, Williams WC, Riddle MM, Andrews DL, Luebke RW, Copeland CB
- Year:
- 1 992
- Bibliographic source:
- Fundament Appl Toxicol 18, 621-627
Materials and methods
- Principles of method if other than guideline:
- Method: other: immune response to TNP-LPS by PFC assay
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-ethoxyethanol
- EC Number:
- 203-804-1
- EC Name:
- 2-ethoxyethanol
- Cas Number:
- 110-80-5
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 2-ethoxyethan-1-ol
- Details on test material:
- Name of the test substance as stated in the publication: 2-ethoxyethanol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Fischer 344 (CDF[F344]/CrlBr
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water
- No. of animals per sex per dose:
- 6
- Control animals:
- yes, concurrent vehicle
Results and discussion
Any other information on results incl. tables
Exposure of rats to the test substance failed to alter the antibody response to TNP-LPS:
| Treatment (mg/kg/day) | PFC / 10^6 cells | PFC / spleen (x 10^(-4)) | Cells /spleen (x 10^(-6)) | Titer (log2) |
| 0 | 502 +/-61 | 30.4 +/- 4.0 | 607 +/-36 | 4.7 +/-0.2 |
| 50 | 408 +/-51 | 254 +/-3.9 | 614 +/-35 | 5.5 +/-0.4 |
| 100 | 678 +/-76 | 38.9 +/-6.2 | 562 +/-27 | 5.2 +/-0.5 |
| 200 | 427 +/-39 | 22.8 +/-1.6 | 540 +/-26 | 3.3 +/-0.3 |
| 400 | 505 +/-86 | 26.0 +/-4.7 | 515 +/-15 | 3.5 +/-0.3 |
Applicant's summary and conclusion
- Conclusions:
- The exposure of male Fischer 344 rats to the test substance 2-ethoxyethanol did not affect the antibody response to TNP-LPS.
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