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Toxicological information

Carcinogenicity

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Description of key information

Chemical Industry Institute of Toxicology" (1981), chronic inhalation of DMA by rats and mice, no carcinogenic effects.

Key value for chemical safety assessment

Additional information

The Chemical Industry Institute of Toxicology investigated in 1981 the carcinogenic potential of DMA. They administered DMA to rats and mice via inhalation in 3 different doses (10, 50 and 175 ppm) and could not show substance-related carcinogenic potential after an administration of DMA for a period of 2 years. The exhibited clinical signs were in high incidence: alopecia, anogenital injuries (♂), beside that irritation around the eyes occurred. A large number of microscopic non-neoplastic lesions were observed including benign and malignant neoplasms. However, only those lesions observed in the mucosal lining of the nasal cavity were considered to be treatment-related and the remainder lesions were those normally expected in rats over 2 years of age.Chronic DMA exposure of rats was not associated with any increase in neoplasia of the nasal passage. In conclusion, it is stated that DMA is not carcinogenic in rats or mice after inhalation exposure.

Justification for classification or non-classification

Classification is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.