Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: publication
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Respiratory and Dermal Exposure to Organophosphorus Flame Retardants and Tetrabromobisphenol A at Five Work Environments
Author:
Maija S. E. Mäkinen, Milja R. A. Mäkinen, Jaana T. B. Koistinen, Anna-Liisa Pasanen, Pertti O. Pasanen, Pentti J. Kalliokoski and Anne M. Korpi
Year:
2009
Bibliographic source:
Environ. Sci. Technol., 2009, 43 (3), pp 941–947

Materials and methods

Endpoint addressed:
other: respiratory and dermal exposure
Principles of method if other than guideline:
• Air sampling and detection methods are given
• Patch samples were used for the dermal exposure estimation.
• Analysis was done using GC/MS
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
To estimate the occupational exposure to TBBA via air sampling at four different occupational setting where FR-containing materials were used or processed and at two types of nonindustrial occupational settings, air sampling was performed. in orderto asses dermal exposure, Patch samples were used.
the chemicals were analyzed using GC/MS

Results and discussion

Results:
• Highest TBBA level was found in electronics dismantling facilities. In the personal samples more than in the stationary air samples.
• In the patch samples measurements, TBBA was found only in electronics dismantling facilities samples

Applicant's summary and conclusion

Conclusions:
• TBBA was considered site-specific in terms of worker’s exposure
• Dermal exposure should be further investigated