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Toxicological information

Carcinogenicity

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Description of key information

A waiver is proposed for this endpoint.

Key value for chemical safety assessment

Additional information

e-caprolactone is non mutagenic in the Ames test (OECD 471) and the HPRT test (OECD476). No clastogenicity was found in a chromosomal aberration test (OECD 473). Beyond this in-vivo mutagenicity data is negative as well. Therefore e-caprolactone is considered to be clearly non mutagenic. According to Column 2 of Annex X of the REACH Regulation it is not necessary to conduct a carcinogenicity study. Beyond this there are no hints for a possible secondary cancer mechanism; e-caprolactone therefore is expected to be non carcinogenic.

Justification for classification or non-classification